DSIP | 10 vials

DSIP (Delta Sleep-Inducing Peptide) is a endogenous nonapeptide (nine amino acids) first isolated in 1977 from the cerebral venous blood of rabbits undergoing hypnogenic electrical stimulation of the thalamus . It was initially characterized by its ability to enhance delta EEG activity—the slow-wave sleep pattern—and has since been recognized as a multifunctional regulatory peptide with diverse physiological effects beyond sleep induction .

Key Specifications:

• CAS Number: 62568-57-4

• Synonyms: Emideltide, Delta Sleep-Inducing Peptide

• Amino Acid Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

• Molecular Formula: C₃₅H₄₈N₁₀O₁₅

• Molecular Weight: 848.81 Da

• Purity: ≥95-99% (research grade)

• Appearance: White lyophilized powder

• Solubility: Soluble in water (0.5 mg/mL)

• Storage: Store at -20°C; protect from light and moisture

Mechanism of Action:

DSIP functions through multiple pathways in the central nervous system:

• Alpha-1 adrenergic receptor modulation: DSIP modulates the response of alpha-1 adrenergic receptors to adrenergic agonists, influencing neurotransmitter signaling

• Neuronal release: DSIP is released from nerve endings upon depolarization and is inactivated by membrane-associated puromycin-sensitive aminopeptidase, suggesting it functions as a neuropeptide-like substance

• Neurotransmitter modulation: Influences levels of key neurotransmitters including 5-HT (serotonin), glutamate, dopamine, and melatonin

• Blood-brain barrier penetration: Can cross the blood-brain barrier, enabling central effects after peripheral administration

Key Research Applications:

Important Notice:

FOR RESEARCH USE ONLY. NOT FOR HUMAN USE, THERAPEUTIC, OR DIAGNOSTIC APPLICATIONS