AICAR | 10 vials

AICAR (5-aminoimidazole-4-carboxamide ribonucleotide), also known as Acadesine, is a synthetic nucleoside compound that functions as a potent activator of AMP-activated protein kinase (AMPK)—a master cellular energy sensor often described as a "metabolic master switch" . Originally investigated for cardiac applications, AICAR gained widespread attention for its ability to mimic the effects of endurance exercise at the cellular level .

Key Specifications:

• CAS Number: 2627-69-2

• Molecular Formula: C₉H₁₄N₄O₅

• Molecular Weight: 258.23 g/mol

• Synonyms: Acadesine, AICA-Riboside, NSC 105823

• Purity: ≥98% (research grade)

• Appearance: White to off-white powder

• Solubility: Soluble in DMSO and water

• Storage: Store at -20°C; protect from light and moisture

Mechanism of Action:

AICAR enters cells and is phosphorylated to form ZMP, an analog of AMP that activates AMPK without altering cellular energy charge . This triggers a cascade of metabolic effects:

• AMPK activation: Mimics cellular energy stress, promoting catabolic pathways

• Glucose uptake: Increases GLUT4 translocation and glucose transport in muscle cells

• Fatty acid oxidation: Enhances mitochondrial fat burning

• Mitochondrial biogenesis: Stimulates new mitochondria formation

• Gene expression: Induces oxidative metabolic genes similar to exercise training

Key Research Applications:

Important Notice:

FOR RESEARCH USE ONLY. NOT FOR HUMAN USE, THERAPEUTIC, OR DIAGNOSTIC APPLICATIONS.