5-amino-1mq | 10 vials
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule compound that functions as a selective inhibitor of nicotinamide N-methyltransferase (NNMT) . It is often referred to as an NNMT inhibitor or NNMTi.
Key Specifications:
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CAS Number: 42464-96-0
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Molecular Formula: C₁₀H₁₁N₂⁺ (cation) / C₁₀H₁₁N₂·I (iodide salt)
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Molecular Weight: 159.21 g/mol (cation); 286.11 g/mol (iodide salt)
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Purity: ≥98-99% (research grade)
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Appearance: Reddish brown to orange powder
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Solubility: Soluble in water and DMSO
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Storage: Store at -20°C; protect from light and moisture
Mechanism of Action:
5-Amino-1MQ inhibits NNMT, an enzyme that consumes nicotinamide (a precursor to NAD+) . By blocking NNMT, it:
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Increases intracellular NAD+ levels (approximately 1.2-1.6-fold)
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Activates SIRT1 (the "longevity gene") via elevated NAD+
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Reduces 1-methylnicotinamide (1-MNA) levels
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Enhances cellular energy expenditure and fat oxidation
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Suppresses lipogenesis (fat cell formation)
Key Research Applications:
| Category | Applications |
|---|---|
| Metabolic health | Obesity, weight management, insulin sensitivity |
| Muscle health | Muscle regeneration, sarcopenia, myoblast differentiation |
| Longevity | NAD+ boosting, SIRT1 activation, cellular energy |
| Cancer research | Ovarian cancer metastasis models |
| Muscle injury | Enhances muscle stem cell (muSC) regeneration |
Preclinical Efficacy Data:
| Model | Dosage | Key Findings |
|---|---|---|
| Diet-induced obese mice | 20 mg/kg SC, 3x daily, 11 days | Progressive body weight loss; reduced fat mass; decreased adipocyte size; lowered cholesterol |
| Muscle injury model | 5-10 mg/kg SC, 2 weeks | 60-75% higher incidence of proliferating muscle stem cells; improved muscle regeneration |
| Ovarian cancer model | 20 mg/kg IP daily | Reduced HeyA8 metastasis |
| 3T3-L1 adipocytes | 30 μM | Reduced lipogenesis; increased NAD+ |
Important Notice:
FOR RESEARCH USE ONLY. NOT FOR HUMAN USE, THERAPEUTIC, OR DIAGNOSTIC APPLICATIONS.
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Key Benefits
- High purity research compound (>98%)
- Third-party tested and verified
- Lyophilized for maximum stability
- Certificate of analysis available
