NAD+ | 10 vials

NAD+ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme found in every living cell, often described as a cellular "fuel regulator" or "youth molecule" . It is essential for hundreds of biochemical reactions, including energy production, DNA repair, and cellular defense mechanisms . NAD+ levels naturally decline with age—by approximately 50% between ages 40 and 60—contributing to age-related decline and disease .

Key Specifications:

• CAS Number: 53-84-9

• Molecular Formula: C₂₁H₂₇N₇O₁₄P₂

• Molecular Weight: 663.43 g/mol

• IUPAC Name: Adenosine 5'-(trihydrogen diphosphate) P'→5'-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium inner salt

• Synonyms: Coenzyme I, Codehydrogenase I, Diphosphopyridine nucleotide, NAD, NADIDE

• Purity: ≥95-98% (research grade)

• Appearance: White to off-white powder

• Storage: Store at -20°C; protect from light and moisture

Mechanism of Action:

NAD+ functions through multiple critical pathways:

• Redox cofactor: Transfers electrons in metabolic reactions (glycolysis, TCA cycle, oxidative phosphorylation)

• Sirtuin activation: Fuels sirtuins (SIRT1-7), proteins that regulate aging, inflammation, and stress resistance

• PARP substrate: Required for PARP enzymes to repair DNA damage

• Second messenger precursor: Converted to calcium-signaling molecules (cADPR, NAADP)

Research Applications:

Clinical Evidence:

A 2026 systematic review of 33 human studies confirmed that oral NAD+ precursors (NR and NMN) consistently increase blood NAD+ levels and are well-tolerated, though effects on functional outcomes remain heterogeneous . A 2026 randomized trial showed NR and NMN supplementation increases circulatory NAD+ concentrations comparably in healthy adults .

Important Notice:

FOR RESEARCH USE ONLY. NOT FOR HUMAN USE, THERAPEUTIC, OR DIAGNOSTIC APPLICATIONS.