MOTS-C | 10 vials
MOTS-c (Mitochondrial ORF of the Twelve S rRNA-c) is a 16-amino acid mitochondrial-derived peptide (MDP) encoded by the 12S rRNA region of the mitochondrial genome . Discovered in recent years, it represents a novel class of bioactive peptides that act as mitochondrial hormones, regulating cellular metabolism and stress responses .
Key Specifications:
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Molecular Formula: C₆₉H₁₁₁N₂₁O₁₈S (approx.)
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Molecular Weight: ~1587 Da
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Sequence: 16 amino acids
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Purity: ≥95-98% (research grade)
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Appearance: Lyophilized powder
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Storage: Store at -20°C
Mechanism of Action: MOTS-c acts as a mitochondrial signaling molecule with pleiotropic effects :
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AMPK pathway activation: Enhances AMPK activity, promoting glucose uptake, fatty acid oxidation, and mitochondrial biogenesis
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Nuclear translocation: During metabolic stress, MOTS-c translocates to the nucleus and regulates nuclear gene expression
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Insulin sensitivity: Improves insulin sensitivity in skeletal muscle and systemic glucose metabolism
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Anti-inflammatory effects: Reduces pro-inflammatory cytokines and oxidative stress
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Cellular stress adaptation: Supports cellular adaptation during metabolic stress (fasting, exercise)
Key Research Applications:
| Category | Applications |
|---|---|
| Metabolic disorders | Type 2 diabetes, insulin resistance, obesity |
| Aging & longevity | Age-related decline, sarcopenia, frailty |
| Muscle health | Sarcopenia, muscle function, exercise adaptation |
| Cardiovascular | Heart failure, diabetic cardiomyopathy, cardiac protection |
| Neurodegeneration | Potential neuroprotective effects |
| Inflammation | Systemic inflammatory responses, pulmonary fibrosis |
Important Notice: FOR RESEARCH USE ONLY. NOT FOR HUMAN USE, THERAPEUTIC, OR DIAGNOSTIC APPLICATIONS.
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Key Benefits
- High purity research compound (>98%)
- Third-party tested and verified
- Lyophilized for maximum stability
- Certificate of analysis available
