BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids, derived from a protective protein found in human gastric juice . First described in scientific literature in 1993, it represents a fragment of the larger body protection compound and is also known as Bepecin, PL 14736, and PL10 .
Key Specifications:
CAS Number: 137525-51-0
Molecular Formula: C₆₂H₉₈N₁₆O₂₂
Molecular Weight: 1419.55 g/mol
Sequence: H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH
Purity: ≥97%
Appearance: Sterile filtered white lyophilized powder
Solubility: Soluble in sterile 18MΩ-cm H₂O (≥100 µg/ml)
Storage: Store lyophilized powder below -18°C; after reconstitution, store at 4°C for 2-7 days or below -18°C for long-term
Mechanism of Action: BPC-157 exhibits pleiotropic regenerative effects through multiple pathways:
Promotes angiogenesis and new blood vessel growth
Modulates the nitric oxide (NO) system, balancing NO levels and counteracting free radical formation
Enhances growth hormone receptor expression and activates Src family kinases (c-Src, Yes, Fyn) via SH3 domain engagement, leading to FAK-ERK and PI3K-Akt signaling cascades
Reduces inflammatory cytokines
Stimulates collagen formation and fibroblast infiltration
Research Applications:
Gastrointestinal healing: Protects gastric mucosa, promotes ulcer healing, and supports intestinal integrity
Musculoskeletal repair: Enhances healing of muscle injuries, tendon ruptures, ligament tears, and fractures in preclinical models
Wound healing: Accelerates skin burn healing by increasing blood flow to damaged tissues
Neuroprotection: Counteracts Parkinson's disease-like and Alzheimer's disease-like disturbances in animal models
Anti-inflammatory effects: Reduces local inflammation in various tissue injury models
Safety Profile: Preclinical studies show no adverse effects across several organ systems, with LD1 not achieved . The peptide demonstrates remarkable chemical stability, maintaining biological activity even under harsh conditions . Half-life is less than 30 minutes, with metabolism in the liver and clearance by the kidneys .
Important Notice: FOR RESEARCH USE ONLY. NOT FOR HUMAN USE, THERAPEUTIC, OR DIAGNOSTIC APPLICATIONS.
BPC-157 is NOT FDA approved and lacks robust human clinical trials . The US FDA has issued warning letters regarding unapproved BPC-157 products marketed for human use . This product is intended for laboratory research purposes only. Researchers should consult relevant literature and institutional guidelines for proper usage.
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