Tirzepatide is a first-in-class, 39-amino acid synthetic peptide that functions as a dual agonist of the GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors . This novel "twincretin" mechanism leverages the synergistic effects of two key incretin hormones to provide metabolic benefits that surpass those of selective GLP-1 receptor agonists .
Key Specifications:
CAS Number: 2023788-19-2
Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈
Molecular Weight: 4813.53 g/mol
Sequence Length: 39 amino acids
Purity: ≥99%
Half-life: Approximately 5 days (supports once-weekly administration)
Mechanism of Action: Tirzepatide activates both GIP and GLP-1 receptors, leading to:
Glucose-dependent insulin secretion
Reduced glucagon release
Delayed gastric emptying
Decreased food intake and increased satiety
Research Applications:
Type 2 diabetes and glycemic control (SURPASS program)
Obesity and weight management studies (SURMOUNT program)
Obstructive sleep apnea (SURMOUNT-OSA)
Metabolic-associated steatohepatitis (SYNERGY-NASH)
Cardiovascular outcomes research
Research Use Only. Not for human consumption.
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