GHRP-6 Acetate | 10 vials
GHRP-6 (Growth Hormone-Releasing Peptide-6) is a synthetic hexapeptide (six amino acids) that acts as a potent growth hormone secretagogue. First developed in the early 1980s, it was one of the original synthetic peptides designed to stimulate growth hormone (GH) release from the pituitary gland .
Key Specifications:
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Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂
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Molecular Weight: Approximately 872 Da
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Purity: ≥95-98% (research grade)
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Appearance: White lyophilized powder
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Storage: Store at -20°C; protect from light and moisture
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Synonyms: Growth hormone-releasing peptide-6, GHRP-6, Hexapeptide
Mechanism of Action:
GHRP-6 functions as an agonist at the growth hormone secretagogue receptor 1 alpha (GHS-R1α) , the same receptor targeted by the natural hormone ghrelin . Key features include:
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GHS-R1α activation: Binds to and activates the ghrelin receptor in the pituitary gland and hypothalamus
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Synergistic GH release: Acts synergistically with growth hormone-releasing hormone (GHRH) to stimulate GH secretion
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Distinct receptor from GHRH: Acts through a different receptor pathway than GHRH, allowing additive effects
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Somatostatin inhibition: May help overcome somatostatin's inhibitory effects on GH release
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Orexigenic effects: Stimulates appetite and food intake by mimicking ghrelin's action in the hypothalamus
Key Research Applications:
| Category | Applications |
|---|---|
| Growth Hormone Research | GH secretion studies, GHRH/GHRP synergy, somatotroph function |
| Cardioprotection | Prevents doxorubicin-induced myocardial damage; reduces ventricular dilation and preserves cardiac function |
| Neuroprotection | Brain damage restoration in combination with EGF (patented application) |
| Appetite Stimulation | Orexigenic effects via hypothalamic activation |
| Tissue Repair | Anti-apoptotic effects in cardiac and endothelial cells |
Clinical Safety:
A Phase I clinical trial in healthy volunteers (doses up to 400 μg/kg) demonstrated an acceptable safety profile with no serious adverse events reported. Adverse effects were mild and transient .
Important Notice:
FOR RESEARCH USE ONLY. NOT FOR HUMAN USE, THERAPEUTIC, OR DIAGNOSTIC APPLICATIONS.
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Key Benefits
- High purity research compound (>98%)
- Third-party tested and verified
- Lyophilized for maximum stability
- Certificate of analysis available
