CJC-1295 with DAC is a synthetic peptide analog of growth hormone-releasing hormone (GHRH) modified with a Drug Affinity Complex (DAC) moiety that binds to serum albumin, extending its half-life to approximately 8 days . It is a 30-amino acid peptide designed for sustained growth hormone release .
Key Specifications:
CAS Number: 446262-90-4
Molecular Formula: C₁₆₅H₂₆₉N₄₇O₄₆
Molecular Weight: ~3647 Da
Sequence: YADAXFXQSYRKVLAQLSARKLLQDXLSR (where X represents specific modifications)
Purity: ≥98% (research grade)
Appearance: Lyophilized powder
Storage: Store at -20°C
Mechanism of Action:
CJC-1295 with DAC functions through several key mechanisms :
GHRH receptor agonism: Binds to GHRH receptors in the anterior pituitary gland, stimulating the secretion of growth hormone (GH)
Albumin binding: The DAC moiety covalently binds to serum albumin, protecting the peptide from rapid degradation and extending its circulatory half-life
Sustained GH release: Provides prolonged stimulation of GH secretion over days rather than hours
IGF-1 elevation: Increases insulin-like growth factor 1 (IGF-1) levels downstream of GH stimulation
Key Research Applications:
| Category | Applications |
|---|---|
| Growth Hormone Research | Sustained GH pulse studies, somatotroph function, IGF-1 axis regulation |
| Metabolic Research | Lipolysis, energy homeostasis, glucose metabolism, body composition studies |
| Tissue Repair | Protein synthesis, cellular regeneration, connective tissue healing |
| Anti-Aging Research | Age-related GH decline, cellular senescence, body composition |
| Muscle Research | Lean mass preservation, protein synthesis, muscle recovery |
Important Notice:
FOR RESEARCH USE ONLY. NOT FOR HUMAN USE, THERAPEUTIC, OR DIAGNOSTIC APPLICATIONS.
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